Growth mechanism study of clustered aggregates of dirithromycin crystals in N, N-dimethylformamide solvent

摘要

A novel self-aggregated cluster of the pharmaceutical compound dirithromycin was observed through a solvent evaporation-induced method. The initial y-elongated hexagonal crystals experienced repeat attachment and growth process, according to the growth law of critical size. and adsorption angle., to assemble such unique clustered aggregates. These results suggest that the solvent plays a critical role in the crystal growth of aggregated clusters of dirithromycin. The oriented attachment and the interaction between the solvent N, N-dimethylformamide (DMF) and the solute dirithromycin were used to rationalize the observed morphologies of the aggregates.