Surface Wrinkling and Porosity of Polymer Particles toward Biological and Biomedical Applications

Visaveliya Nikunjkumar R.; Leishman Christopher W.; Ng Kara; Yehya Nicolas; Tobar Nelson; Eisele Dorthe M.; K?hler Johann Michael

摘要

Abstract >Polymer particles are promising particulate materials for renowned biomedical applications such as targeted drug delivery, tissue engineering, and biosensing. Surface properties of the polymer particles are of key importance for biomedical applications because they directly interact with biological systems. Particularly, wrinkled as well as porous surfaces possess an enhanced ability for cell attachment without any additional chemical modification. Therefore, a key objective is to fabricate the particles with desired degree of wrinkles and porosity. Many methods such as solvent evaporation, plasma treatment, emulsion instability, and electrospraying are being employed for the generation of porous, wrinkled and/or textured surfaces. Advantageously, an application of microfluidics can support the induction of surface instabilities on droplets in a case of droplet‐based systems. Furthermore, microfluidics allows tuning of size and shape of the generated droplets as well as particles with desired surface textures. In this minireview article, surface characteristics (especially surface wrinkles and porosity) of the hydrophobic and hydrophilic polymer particles are presented for the potential applications toward biological as well as biomedical field. In addition, the impact of microfluidics is highlighted in order to produce the polymer particles of functional surface properties. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >聚合物颗粒是具有着名生物医学应用的颗粒材料，例如靶向药物递送，组织工程和生物传感。聚合物颗粒的表面性质对生物医学应用具有重要性，因为它们与生物系统直接相互作用。特别地，皱纹和多孔表面具有增强的细胞连接能力，而无需任何额外的化学改性。因此，关键目标是制造具有所需皱纹和孔隙度的颗粒。许多方法，例如溶剂蒸发，等离子体处理，乳液不稳定性和电喷雾器用于产生多孔，皱纹和/或纹理表面。有利地，在基于液滴的系统的情况下，微流体的应用可以支持在液滴上的表面稳定性的诱导。此外，微流体允许调谐产生的液滴的尺寸和形状以及具有所需表面纹理的颗粒。在该MINIREVIEW制品中，疏水和亲水性聚合物颗粒的表面特性（尤其是表面皱纹和孔隙率）用于潜在的应用朝向生物和生物医学领域。此外，突出了微流体的影响，以产生功能性表面性质的聚合物颗粒。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18063/'>《Advanced materials interfaces》</a> <b style="margin: 0 2px;">|</b><span>2017年第24期</span><b style="margin: 0 2px;">|</b><span>共15页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Visaveliya Nikunjkumar R.&option=202" target="_blank" rel="nofollow">Visaveliya Nikunjkumar R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Leishman Christopher W.&option=202" target="_blank" rel="nofollow">Leishman Christopher W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ng Kara&option=202" target="_blank" rel="nofollow">Ng Kara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yehya Nicolas&option=202" target="_blank" rel="nofollow">Yehya Nicolas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tobar Nelson&option=202" target="_blank" rel="nofollow">Tobar Nelson;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eisele Dorthe M.&option=202" target="_blank" rel="nofollow">Eisele Dorthe M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=K?hler Johann Michael&option=202" target="_blank" rel="nofollow">K?hler Johann Michael;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Physical Chemistry and Microreaction TechnologyTechnical University of Ilmenau32 Weimarer Strasse 98693 Ilmenau Germany;</p> <p>Department of Chemistry and Biochemistry and Center for Discovery and Innovationthe City College of New York of the City University of New York160 Convent Avenue New York NY 10031 USA;</p> <p>Department of Chemistry and Biochemistry and Center for Discovery and Innovationthe City College of New York of the City University of New York160 Convent Avenue New York NY 10031 USA;</p> <p>Department of Chemistry and Biochemistry and Center for Discovery and Innovationthe City College of New York of the City University of New York160 Convent Avenue New York NY 10031 USA;</p> <p>Department of Chemistry and Biochemistry and Center for Discovery and Innovationthe City College of New York of the City University of New York160 Convent Avenue New York NY 10031 USA;</p> <p>Department of Chemistry and Biochemistry and Center for Discovery and Innovationthe City College of New York of the City University of New York160 Convent Avenue New York NY 10031 USA;</p> <p>Department of Physical Chemistry and Microreaction TechnologyTechnical University of Ilmenau32 Weimarer Strasse 98693 Ilmenau Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biointeractions&option=203" rel="nofollow">biointeractions;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microfluidics&option=203" rel="nofollow">microfluidics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymer particles&option=203" rel="nofollow">polymer particles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=porosity&option=203" rel="nofollow">porosity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surface tension&option=203" rel="nofollow">surface tension;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=wrinkled surfaces&option=203" rel="nofollow">wrinkled surfaces;</a> </p> <div class="translation"> 机译：生物宁珠;微流体;聚合物颗粒;孔隙率;表面张力;皱纹表面; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022434532.html">Structured Particulate Materials: Surface Wrinkling and Porosity of Polymer Particles toward Biological and Biomedical Applications (Adv. 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class="tuijian_auth tuijian_authcolor"> . 陈宝林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王东安&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王东安</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2015</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-tissue-engineering-research_thesis/0201252075706.html">用于心血管医疗装置的聚合物材料表面构建与生物相容性研究Ⅱ-心血管医疗装置聚合物的表面构建与生物反应行为</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈宝林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈宝林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王东安&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王东安</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2014</span><span>,第021期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-4974_thesis/020221211408.html">用于心血管医疗装置的聚合物表面构建与生物相容性研究——用于心血管医疗的聚合物生物材料及其表面研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈宝林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈宝林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王东安&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王东安</a> <span> <a href="/conference-cn-4974/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第八届内蒙古自治区自然科学学术年会 </a> <span> <span> . 2013</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314663759.html">含偶氮聚合物膜表面皱纹的光擦除与光调制研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=宗传永&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 宗传永</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204930464.html">用于生物医学应用的聚合物材料</a> <b>[P]</b> . <span> 中国专利： CN108472120B </span> <span> . 2022.02.25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120110980892.html">用于生物医学应用的聚合物材料</a> <b>[P]</b> . <span> 中国专利： CN108472120A </span> <span> . 2018-08-31</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130462671853.html">Polymer particles which carry, implanted on their surface, amphiphilic molecules carrying ion-forming or reactive groups, a process for the preparation of these particles and their use in biological applications</a> <b>[P]</b> . <span> 外国专利：  US5109038A </span> <span> . 1992-04-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在其表面上植入带有离子形成或反应性基团的两亲分子的聚合物颗粒，制备这些颗粒的方法及其在生物应用中的用途 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130464479954.html">POLYMER PARTICLES WHICH CARRY IMPLANTED ON THEIR SURFACE AMPHIPHILIC MOLECULES CARRYING ION-FORMING OR REACTIVE GROUPS A PROCESS FOR THE PREPARATION OF THESE PARTICLES AND THEIR USE IN BIOLOGICAL APPLICATIONS</a> <b>[P]</b> . <span> 外国专利：  KR910009292B1 </span> <span> . 1991-11-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：携带有离子形成基团或反应性基团的表面两亲分子上带有聚合物的聚合物颗粒的制备方法及其在生物应用中的用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130465515696.html">Polymer particles which carry, implanted on their surface, amphiphilic molecules carrying ion-forming or reactive groups, a process for the preparation of these particles and their use in biological applications</a> <b>[P]</b> . <span> 外国专利：  US4952622A </span> <span> . 1990-08-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在其表面上植入带有离子形成或反应性基团的两亲分子的聚合物颗粒，制备这些颗粒的方法及其在生物应用中的用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022434409','4',7,2,1,'',this,24)" class="delivery" 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