Comparison of remineralization by fluoride varnishes with and without casein phosphopeptide amorphous calcium phosphate in primary teeth

摘要

Objective: To compare Ml (5% NaF with 2% CPP-ACP) and Prevident (5% NaF) varnishes in remineral-izing caries-like lesions in primary teeth regarding calcium and phosphate enamel content and lesion depth. Material and methods: Caries-like lesions were created in 48 primary teeth which were divided into 2 halves; one left untreated (control) and the other half treated with Ml or Prevident varnishes. Calcium and phosphate content was assessed using energy dispersive X-ray spectrometer and reduction in lesion depth was assessed using polarized light microscopy. Demineralization and remineralization values in each group were compared using paired f test and percentage change between groups was compared using f test and Mann Whitney U test. Results: A greater percentage increase of calcium was observed in Ml than Prevident specimens (median = 8.97 and 2.67, p<.0001), with greater calcium phosphate ratio percentage increase (median = 28.96 and 7.40) and phosphate percentage reduction (median = 15.5 and 4.51). The mean (SD) percentages reduction in lesion depth in the Ml varnish was significantly greater than in Prevident varnish (44.41 (7.12) and 22.73 (9.35), p<.0001). Conclusions: Ml varnish had better remineralization effect in primary teeth than Prevident varnish in terms of higher mineral content and shallower lesion depth.