Is the incidence of recurrent pregnancy loss increasing? A retrospective register‐based study in Sweden

Rasmark Roepke Emma; Matthiesen Leif; Rylance Rebecca; Christiansen Ole Bjarne

摘要

Abstract <section xml:id="aogs13210-sec-0001"> <title type="main">Introduction > The aim of this study was to estimate the incidence of recurrent pregnancy loss ( <fc>RPL</fc> ). The prevalence of <fc>RPL</fc> defined as three or more consecutive miscarriages before gestation week 22, is often stated to be 1%. To our knowledge no study has estimated the incidence of <fc>RPL</fc> , which might be more informative and clinically relevant than the prevalence. </section> <section xml:id="aogs13210-sec-0002"> <title type="main">Material and methods > This retrospective register‐based study was conducted from 2003 until 2012 in Sweden with data provided by the Swedish National Board of Health and Welfare. In all, 6852 women were registered with the diagnoses of <fc>RPL</fc> in the National Patient Register. The incidence of <fc>RPL</fc> is the number of new women receiving the <fc>RPL</fc> diagnosis per year in the numerator and population at risk in the denominator. </section> <section xml:id="aogs13210-sec-0003"> <title type="main">Results > For each year, from 2003 to 2012, the incidence was calculated in two different risk populations: [1] all women aged 18–42?years, and [2] all women registered as being pregnant (deliveries or miscarriages). The average incidence in the study period was 53 per 100?000 (0.05%) in women aged 18–42?years and 650 per 100?000 (0.65%) in women who had achieved pregnancy in the period. The incidence of <fc>RPL</fc> in the two risk populations increased by 74 and 58%, respectively, during the study period. </section> <section xml:id="aogs13210-sec-0004"> <title type="main">Conclusion > This study suggests that the incidence of <fc>RPL</fc> increased during the 10‐year period studied. Causes can only be speculated upon in this study design, but might be associated with environmental changes, as the increase was fairly rapid. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“aogs13210-abs-0001”> <title type =“main”>抽象</ title> <第XML：ID =“AOGS13210-SEC-0001”> <标题类型=“main”>介绍</ title> >本研究的目的是估算复发性妊娠损失的发生率（<fc> rpl </ FC>）。在妊娠周22之前定义为三个或更多个连续流产的患病率通常表示为1％。对于我们的知识，没有研究估计<FC> rpl </ fc>的发病率，这可能比流行率更丰富和临床相关。 </ p> </ section> <section XML：ID =“AOGS13210-SEC-0002”> <标题类型=“main”>材料和方法</ title> >本回顾性寄存器的研究是从2003进行的直到2012年，瑞典都有瑞典国家健康委员会提供的数据。总之，6852名妇女在国家患者登记册中诊断了<FC> RPL </ FC>。 <Fc> rpl </ fc>的发病率是在分数仪中每年接受<FC> RPL </ FC>诊断的新妇女的数量。 </ p> </ section> <section xml：id =“aogs13210-sec-0003”> <标题类型=“main”>结果每年</ title> >，从2003年到2012年，发病率是在两种不同的风险群体中计算：[1]所有18-42岁的女性？年份和[2]所有妇女都注册为怀孕（交付或流产）。研究期的平均发病率为18-42岁的妇女每100 000（0.05％）为53岁（0.05％）？年龄和650 000（0.65％）在此期间达到怀孕的妇女。在研究期间，两个风险群体中<FC> RPL </ FC>在两个风险群体中的发病率分别增加了74％和58％。 </ p> </ section> <section XML：ID =“AOGS13210-SEC-0004”> <标题类型=“main”>结论</ title> >本研究表明<fc> rpl的发病率< / FC>在研究的10年期间增加。只有在本研究设计中只能推测原因，但可能与环境变化有关，因为增加相当迅速。 </ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-17780/'>《Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rasmark Roepke Emma&option=202" target="_blank" rel="nofollow">Rasmark Roepke Emma;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matthiesen Leif&option=202" target="_blank" rel="nofollow">Matthiesen Leif;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rylance Rebecca&option=202" target="_blank" rel="nofollow">Rylance Rebecca;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Christiansen Ole Bjarne&option=202" target="_blank" rel="nofollow">Christiansen Ole Bjarne;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Obstetrics and GynecologySk?ne University HospitalMalm? Sweden;</p> <p>Department of Obstetrics and GynecologyAffiliated Lund UniversityHelsingborg Sweden;</p> <p>Department of Research and DevelopmentSk?ne University HospitalLund Sweden;</p> <p>Fertility Clinic 4071University Hospital RigshospitaletCopenhagen Denmark;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/197.html" title="妇产科学">妇产科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Recurrent pregnancy loss&option=203" rel="nofollow">Recurrent pregnancy loss;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=abortion (habitual)&option=203" rel="nofollow">abortion (habitual);</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=incidence&option=203" rel="nofollow">incidence;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epidemiology&option=203" rel="nofollow">epidemiology;</a> </p> <div class="translation"> 机译：复发妊娠损失;流产（习惯性）;发病率;流行病学; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025828414.html">Is the incidence of recurrent pregnancy loss increasing? 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therefor</a> <b>[P]</b> . <span> 外国专利：  KR102280397B1 </span> <span> . 2021-07-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：PGK1Phogogycoge激酶1使用PGK1Phophycoge激酶1或编码与生物标志物和试剂盒相同的基因来诊断复发性妊娠损失的分析方法 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130500614631.html">Analytical method for diagnosing recurrent pregnancy loss and kit therefor</a> <b>[P]</b> . <span> 外国专利：  KR20210111407A </span> <span> . 2021-09-13</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于诊断复发性妊娠损失和套件的分析方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> 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