Longitudinal bleb morphology in anterior segment OCT OCT after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation

摘要

Abstract Purpose Like the classic trabeculectomy, the minimally invasive, ab interno XEN Glaucoma Gel Microstent ( XEN ‐ GGM ) creates a filtration bleb in the conjunctiva. The goal of this study was to investigate internal bleb morphology over time with anterior segment optical coherence tomography ( AS ‐ OCT ) after XEN ‐ GGM implantation. Methods In a prospective, single‐centre, single‐armed cohort study, blebs were characterized using AS ‐ OCT in 78 eyes of 60 patients at day 1, at weeks 1 and 2 and at months 1, 3, 6, 9 and 12 after XEN ‐ GGM implantation in patients with open‐angle glaucoma. Morphological bleb characteristics were correlated with IOP and surgical success. Results Anterior segment optical coherence tomography data indicate early and late bleb changes in the course of 12?months. Uniform blebs in AS ‐ OCT s showed higher IOP s at all examinations between week 1 (17.7?±?4.8?mmHg versus 11.3?±?7.1?mmHg, p?=?0.001) and month 3 (16.4?±?6.1 versus 13.4?±?6.1, p?=?0.04). Subconjunctival tissue separation bleb morphology was associated with lower mean IOP s during the course of 12?months ( r ?=??0.75, p?=?0.031). Predictors for surgical failure at month 12 were microcystic multiform bleb morphology in AS ‐ OCT at month 3 (60% versus 15%, relative risk 4.0, p?=?0.043) and uniform bleb morphology at month 9 (33% versus 23%, relative risk 1.4, p?=?0.015). Conclusion Bleb appearance after XEN surgery seems to be different to classic trabeculectomy literature. The present data suggest correlation of IOP and surgical long‐term success with bleb morphology in AS ‐ OCT . Prevalence of small diffuse cysts is directly associated with lower IOP s, while cystic encapsulation at 3?months predicts higher surgical failure.