Increased IL-35 producing Tregs and CD19(+)1-35(+) cells are associated with disease progression in leprosy patients

摘要

Background: The clinical forms of leprosy consist of a spectrum that reflects the host's immune response to the M. leprae; it provides an ideal model to study the host pathogen interaction and immunological dysregulation in humans. IL -10 and TGF-beta producing Tregs are high in leprosy patients and responsible for immune suppression and M. leprae specific T cells anergy. In leprosy, involvement of IL-35 producing Tregs and Bregs remain unstudied.