A fluorophore-labelled copper complex: crystal structure, hybrid cyclic water-perchlorate cluster and biological properties

摘要

A fluorophore-labelled copper(II) complex, aquabis(dimethylformamide-κO)-(perchlorato-κO)[2-(quinolin-2-yl)-1,3-oxazolo[4,5-f][1,10]phenanthroline]cop-per(II) perchlorate monohydrate, [Cu(ClO_4)(C_22H_12N_4O)(C_3H_7NO)_2(H_2O)]-ClO_4·H_2O, has been synthesized and characterized. A cyclic hydrogen-bonded water-perchlorate anionic cluster, i.e. [(ClO_4)_2(H_2O)_2] , has been identified within the structure. Each cyclic anionic cluster unit is interconnected by hydrogen bonding to the cation. The cations join into an infinite hydrogen-bonded chain running in the [010] direction. Furthermore, interaction of the complex with calf-thymus DNA (CT-DNA) and cellular localization within the cells was explored. Spectroscopic studies indicate that the compound has a good affinity for DNA and stains the nucleus of the cells.