Planarity of benzoylthiocarbazate tuberculostatics. IV. Polymorphs of N00-(1,3-dithiolan-2-ylidene)-4-nitrobenzohydrazide

摘要

The search for new tuberculostatics is important considering the occurrence of drug-resistant strains of Mycobacterium tuberculosis. Three polymorphs of N'-(1,3-dithiolan-2-ylidene)-4-nitrobenzohydrazide (a potentially tuberculo-static agent), C_10H_9N_3O_3S_2, denoted (I1), (I2) and (I3), and the monohydrate of this compound, C_10H_9N_3O_3S_2-H_20, (I4), have been characterized by single-crystal X-ray diffraction. The conformations of the molecules in all these structures are very similar. Structures (I1), (I2) and (I3) provide an example of packing polymorphism resulting from different intermolecular interactions.