Contribution of hemolysin and phospholipase activity to cytolytic properties and viability of Listeria monocytogenes

摘要

The life cycle of Listeria monocvtogenes strongly depends on cytolysin which facilitates the pathogen's escape from the endosome. This process is very ineffective in the absence of phospholipases. In this study we investigated the molecular mechanismof cooperation between hemolysin and phospholipases. We propose a model involving interactions between proteins that increase the affinity of cytolysins for the membrane as well direct enzymatic enhancement of lysis.