Toll-like Receptors Signaling Pathways as a Potential Therapeutic Target in Cardiovascular Disease

摘要

Cardiovascular Disease (CVD) is one of the most important causes of morbidity and mortality, andassociated with an important economic burden globally. Over the last decade, the prevalence of CVD has beenrising globally, and is now associated with millions of death annually in both developed and developing countries.There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors(TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studieshave suggested that the TLRs are involved in atherogenesis, including stroke, myocardial infarction, ischemiareperfusioninjury, cardiac remodeling and development of Heart Failure (HF). In this review we have summarizedthe recent studies investigating the role of TLRs in CVD and the potential for using TLRs signaling pathwaysas a therapeutic target in CVD.