HPLC-MS Determination and Pharmacokinetic Study of 7, 8-Dihydroxyflavone, a Naturally-Occurring Neuroprotective Agent after a Single Oral Administration in Rats

摘要

Background: 7, 8-dihydroxyflavone (7, 8-DHF) has been discovered to be a TrkB receptor-specific agonist and demonstrated remarkable therapeutic efficacy in vivo. These promising findings prompted the current pharmacokinetic study, in which we first established a practical LC-MS quantitative method for 7, 8-DHF then applied it in a pilot pharmacokinetic study in rats.