Clinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents in children

摘要

PURPOSE OF REVIEW: Procedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department. RECENT FINDINGS: Numerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized. SUMMARY: We review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.