The Role of Biomarker Genes in the Diagnosis and Treatment of Nonsmall Cell Lung Cancer

摘要

Lung cancer has been recognized as the most important reason for death and a lifethreateningdisease. The late diagnosis of this disease usually limits treatment interventions. The lackof reliable noninvasive biomarkers and therapies results in low survival rates. The current review isdesigned to uncover the specific role of biomarker genes involved in the non-small cell lung cancer(NSCLC) and demonstrate their high discrimination power between NSCLC from the normal tissues.So, studying the gene expression differences associated with their network functionality extractedfrom the serum biomarkers will be a helpful approach in predicting them on small cell lung cancer.Nowadays, several analyses based on bioinformatics and computational methodologies havedetermined various genes influencing the healthy and diseased cells for achieving a betterperformance on treatment and prognosis of NSCLC. Although the existing treatments for all stagesof lung cancer including surgery, chemotherapy, or radiation did not show reasonable results,achieving better outcomes in the future may be possible through genetic diagnosis as well as genetherapy techniques.