Moderne Hornhautdiagnostik mithilfe der SD-OCT-Technologie - ein weiterer Meilenstein?

摘要

>Purpose:To investigate the repeatability and reproducibility of mapping the entire corneal thickness using spectral domain optical coherence tomography (SD-OCT).Methods:Thirty normal eyes, 30 post-laser in situ keratomileusis (LASIK) surgery eyes, and 30 keratoconus eyes were analyzed. A custom-built long scan depth SD-OCT device was used to obtain entire corneal images. Ten-millimeter-diameter corneal thickness maps were generated by an automated segmentation algorithm. Intraclass correlation coefficients of repeatability (ICC₁) and reproducibility (ICC₂), and coefficients of repeatability (CoR₁) and reproducibility (CoR₂), were calculated to quantify the precision and accuracy of corneal pachymetry measurements using the Bland-Altman method.Results:For SD-OCT measurements in healthy subjects, CoR₁and CoR₂were less than 5.00 and 5.53 μm. ICC₁and ICC₂were more than 0.997 and 0.996. For SD-OCT measurements in LASIK patients, CoR₁and CoR₂were less than 5.09 and 5.34 μm. ICC₁and ICC₂were more than 0.997 and 0.996. For SD-OCT measurements in keratoconus patients, CoR₁and CoR₂were less than 11.57 and 10.92 μm. ICC₁and ICC₂were more than 0.995 and 0.996.Conclusions:The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.]]>