Relationship between Viscosity and Micellization of Fused Chelates of Thiazine Drugs in Different Chemical Compositions | Bentham Science

摘要

Background: Phenothiazines and Triphenodithiazines are included in the classof nitrogen and sulphur donating ligands. They have a wide spectrum of biological activitiesand form important class of heterocyclic compounds. Both drugs are being used as, antitumors,anti-inflammatory, antiviral, anaesthetics, anticancer agents, antimalarials, antimicrobials,anti-cholinergics, growth inhibitors, and many other pharmacological agents.Objective: Present work has been initiated with a view to obtain a profile regarding structuralinsight of complexes of Cobalt (II), Ni (II) and Zinc (II) soaps derived from substitutedphenothiazines 15 and triphenodithiazines using latest technique. It also gives an accountof micelle formation in the mixed non aqueous solvents.Methods: The viscosity, specific viscosity, and fluidity of complexes of Co, Ni, and ZnOleate with substituted phenothiazine and triphenodithiazine in methanol + benzene solventswas determined at a constant temperature of 303.15 K to study the micellar featuresand critical micelle concentration (CMC). In the present work benzene+ methanol have selectedas co solvents due to these interact with complex molecules and thus affected aggregationof complex molecules.Results: The results were used to determine the CMC, soap complex-solvent interactionsand the effect of chain length of the surfactant molecule on various parameters. The conclusionsconcerning solute-solute and solute-solvent interaction were discussed regardingthe well-known Moulik’s and Jones-Dole equations.Conclusion: From above results it may be concluded that the micelle formation take placeearlier in the case of triphenodithiazine complexes due to larger molecular structure, so asmaller number of molecules are needed to form micelle. Micellization also confirms theexistence of complex aggregation in the non-aqueous mixed solvents. To conclude, it canbe unveiled on the basis of the result acquired that above study of complexes conforms thepresence of complex aggregation in the non - aqueous mixed solvents.