Advancement in Nanotheranostics for Effective Skin Cancer Therapy: State of the Art | Bentham Science

摘要

The skin cancer has become a leading concern worldwide as a result of highmortality rate. The treatment modality involves radiation therapy, chemotherapy or surgery.More often combination therapy of chemotherapeutic agents gives better solutionover single chemotherapeutic agent. The Globocon report suggested that high incidenceand mortality rate in skin cancer is growing day-to-day. This type of cancer is more prevalentin that area where a person is highly exposed to sunlight. The nanotechnology-basedtherapy is nowadays drawing attention and becoming a more important issue to be discussed.The nanotherapy of skin cancer is dealt with various approaches and strategies.The strategic based approaches imply nanoparticles targeting carcinoma cells, functionalizednanoparticles for specific targeting to cancer cells, receptor-mediated active targetingas nanoshells, nanostrutured lipid carriers, liposome, ethosome, bilosome, polymeric nanoparticle,nanosphere, dendrimers, carbon nanotubes, quantum dots, solid lipid nanoparticlesand fullerenes which are highly efficient in specific killing of cancer cells. The passivetargeting of chemotherapeutic agents is also helpful in dealing with carcinoma due toenhanced permeability and retention effect (EPR).The article outlines nano-based therapy currently focused globally, and the outcomes ofthe therapy as well.