Hetero-Diels-Alder Reactions in the Synthesis of Biologically Active Nitrogen Compounds: A Review

摘要

Background: The Hetero-Diels-Alder reaction (HDAR) is a method extensively used in organicchemistry as a tool in the synthesis of innumerous polycyclic compounds in particular nitrogen compounds,presents in many natural products, medicinally relevant substances and organic materials. The literature describesinnumerable studies of HDAR using classic methods and modern developments such as reactions onthe solid phase, the use of catalysts, transformations in aqueous solution and under microwaves.Objective: This review describes a variety of HDAR focused on obtaining nitrogen-containing compounds ofconsiderable chemical and biological interest, and highlighting reported biological activity.Conclusion: This review has shown the importance of the HDA reaction as a tool of organic chemistry in thesynthesis of nitrogen compounds. This type of reaction presents important properties including bond-formingeconomy, high regio- and stereoselectivities and thus provides highly efficient routes to access a wide range ofpolycyclic compounds. In addition to the variety of nitrogen compounds synthetized successfully by thismethod, they present relevant biological properties.