Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis

de Avila Mauricio Boff; Bitencourt-Ferreira Gabriela; de Azevedo Jr Walter Filgueira

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Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis

机译：结核分枝杆菌抑制烯丙基 - α-ε-α还原酶（ONHA）的结构依据

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Background: The enzyme trans-enoyl-[acyl carrier protein] reductase (InhA) is a central protein for the development of antitubercular drugs. This enzyme is the target for the pro-drug isoniazid, which is catalyzed by the enzyme catalase-peroxidase (KatG) to become active.

机译：背景：酶反烯-α-苯基 - [酰基载体蛋白]还原酶（Inha）是用于抗细胞药物的中央蛋白。该酶是药物异烟肼的靶标，该靶由酶过氧化物酶（KATG）催化以变为活性。

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来源
《Current medicinal chemistry》 |2020年第5期|共15页
作者
de Avila Mauricio Boff; Bitencourt-Ferreira Gabriela; de Azevedo Jr Walter Filgueira;
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作者单位

Pontifical Catholic Univ Rio Grande do Sul PUCRS Lab Computat Syst Biol Sch Sci Av Ipiranga 6681;

Pontifical Catholic Univ Rio Grande do Sul PUCRS Lab Computat Syst Biol Sch Sci Av Ipiranga 6681;

Pontifical Catholic Univ Rio Grande do Sul PUCRS Lab Computat Syst Biol Sch Sci Av Ipiranga 6681;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Crystal structure; protein-ligand interactions; trans-enoyl-acyl carrier protein reductase; drug design; InhA inhibitors; enzymes;

机译：晶体结构;蛋白质 - 配体相互作用;反式烯-α-烷酮蛋白质]还原酶;药物设计;inha抑制剂;酶;

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1. Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis [J] . de Avila Mauricio Boff, Bitencourt-Ferreira Gabriela, de Azevedo Jr Walter Filgueira Current medicinal chemistry . 2020,第5期

机译：结核分枝杆菌抑制烯丙基 - α-ε-α还原酶（ONHA）的结构依据
2. Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. [J] . He X, Alian A, Ortiz-de-Montellano PR Bioorganic and medicinal chemistry . 2007,第21期

机译：芳基酰胺对结核分枝杆菌烯酰基酰基载体蛋白还原酶InhA的抑制作用。
3. Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides [J] . Xin He, Akram Alian, Paul R. Ortiz de Montellano Bioorganic and Medicinal Chemistry . 2007,第21期

机译：芳基酰胺对结核分枝杆菌烯酰基酰基载体蛋白还原酶InhA的抑制作用
4. Machine learning approaches for customized docking scores: Modeling of inhibition of Mycobacterium tuberculosis enoyl acyl carrier protein reductase [C] . Fogel Gary B., Tran Jonathan, Johnson Stephen, 2010 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology . 2010

机译：用于定制对接分数的机器学习方法：结核分枝杆菌烯酰基酰基载体蛋白还原酶抑制模型
5. Lead Optimization and Slow-Onset Inhibition of the Enoyl-ACP Reductase (InhA) from Mycobacterium Tuberculosis. [D] . Pan, Pan. 2012

机译：结核分枝杆菌中Enoyl-ACP还原酶（InhA）的前导优化和缓慢抑制。
6. Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides [O] . Xin He, Akram Alian, Paul R. Ortiz de Montellano -1

机译：芳基酰胺对结核分枝杆菌烯酰基酰基载体蛋白还原酶InhA的抑制作用
7. Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides [O] . Xin He, Akram Alian, Paul R. Ortiz de Montellano 2007

机译：芳基酰胺抑制结核分枝杆菌结核酶酰基酰基载体蛋白还原酶inha

Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis

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