MUC1 Story: Great Expectations, Disappointments and the Renaissance

Syrkina Marina S.; Vassetzky Yegor S.; Rubtsov Mikhail A.

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MUC1 Story: Great Expectations, Disappointments and the Renaissance

机译：Muc1故事：非常期望，失望和文艺复兴

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In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed. The therapeutic potential of mucin MUC1 has already been noted by various scientific groups at the early stages of research. Over forty years ago, the first insights into MUC1 functions became a strong ground for considering this molecule as potential target for anticancer therapy. Therefore, this direction of research has always been of particular interest and practical importance, More than 200 papers on MUC1 were published in 2016; the majority of them are dedicated to MUC1-related anticancer diagnostics and therapeutics, Here we review the history of MUC1 studies from the very first attempts to reveal its functions to the ongoing renaissance.

机译：在研究人粘蛋白MUC1的过程中，对该分子的态度再次变化。最初，MUC1的可推定功能列表仅限于保护和润滑上皮。迄今为止，假设从恶性细胞转化到肿瘤传播中，在细胞信号传导以及肿瘤传播中的所有阶段中发挥重要作用。 Muc1的故事充满了希望和失望。然而，对MUC1的科学兴趣从未有过，而且已经更深刻地调查了，更清晰的隐藏潜力转而披露。在研究的早期阶段，各种科学群体已经注意到粘蛋白MUC1的治疗潜力。在四十年前，对MUC1功能的第一次见解成为一个强大的理由，即将该分子视为抗癌疗法的潜在目标。因此，这项研究方向一直是特别的兴趣和实际重要性，2016年出版了200多篇关于Muc1的论文;其中大多数是致力于Muc1相关的抗癌诊断和治疗方法，在这里我们审查了MUC1研究的历史，从第一次尝试揭示其持续的文艺复兴的功能。

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《Current medicinal chemistry》 |2019年第3期|共10页
作者
Syrkina Marina S.; Vassetzky Yegor S.; Rubtsov Mikhail A.;
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作者单位

Moscow MV Lomonosov State Univ Fac Biol Dept Mol Biol Leninskie Gory 1-B12 Moscow 119991 Russia;

Univ Paris Sud Paris Saclay Inst Gustave Roussy CNRS UMR8126 F-94805 Villejuif France;

Moscow MV Lomonosov State Univ Fac Biol Dept Mol Biol Leninskie Gory 1-B12 Moscow 119991 Russia;

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正文语种 eng
中图分类药学;
关键词
MUC1; PEM; anticancer therapy; metastasis; breast cancer; mucin glycoprotein;

机译：muc1;pem;抗癌治疗;转移;乳腺癌;粘蛋白糖蛋白;

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1. MUC1 Story: Great Expectations, Disappointments and the Renaissance [J] . Syrkina Marina S., Vassetzky Yegor S., Rubtsov Mikhail A. Current medicinal chemistry . 2019,第3期

机译：Muc1故事：非常期望，失望和文艺复兴
2. MUC1, the renaissance molecule. [J] . Gendler SJ Journal of mammary gland biology and neoplasia . 2001,第3期

机译：MUC1，文艺复兴时期的分子。
3. MUC1, the renaissance molecule. [J] . Gendler SJ Journal of mammary gland biology and neoplasia . 2001,第3期

机译：MUC1，文艺复兴时期的分子。
4. History of the winter simulaltion conference: Renaissance perod (1975–1982) [C] . Robert G. Sargent, Paul F. Roth, Thomas J. Schriber Simulation Conference . 2017

机译：冬季模拟会议的历史：文艺复兴时期（1975–1982）
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机译：政治失望：一种感觉的部分历史
6. Holding soft objects increases expectation and disappointment in the Cyberball task [O] . Toshiki Ikeda, Yuji Takeda 2012

机译：握住柔软的物体会增加对Cyberball任务的期望和失望
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MUC1 Story: Great Expectations, Disappointments and the Renaissance

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