A Systematic Review of Evidence-based Treatment Strategies for Obsessive-compulsive Disorder Resistant to First-line Pharmacotherapy

摘要

Background: Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). However, a significant proportion of patients do not respond satisfactorily to first-choice treatments. Several options have been investigated for the management of resistant patients.