Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study

Reed Kenneth; Collaku Agron; Moreira Sebastian

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Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study

机译：每日两次持续释放扑热氨基醇制剂的疗效和安全性对膝关节或臀部的骨关节炎疼痛：随机，双盲，安慰剂控制，十二周的研究

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Objective: Evaluate efficacy and safety of an investigational, twice daily sustained-release (SR) paracetamol formulation in subjects with knee or hip osteoarthritis (OA).

机译：目的：评估膝关节或髋关节骨关节炎（OA）的受试者中每日两次持续释放（SR）扑热息醇制剂的疗效和安全性。

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来源
《Current medical research and opinion》 |2018年第4期|共11页
作者
Reed Kenneth; Collaku Agron; Moreira Sebastian;
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作者单位

GlaxoSmithKline Consumer Healthcare Clin Dev &

Med Affairs Parsippany NJ USA;

GlaxoSmithKline Consumer Healthcare Biostat Parsippany NJ USA;

GlaxoSmithKline Consumer Healthcare Clin Dev &

Med Affairs Parsippany NJ USA;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Acetaminophen; analgesics; non-narcotic; pain; osteoarthritis; knee; osteoarthritis; hip;

机译：乙酰氨基酚;镇痛药;非麻醉;疼痛;骨关节炎;膝关节;骨关节炎;臀部;

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1. Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study [J] . Reed Kenneth, Collaku Agron, Moreira Sebastian Current medical research and opinion . 2018,第4期

机译：每日两次持续释放扑热氨基醇制剂的疗效和安全性对膝关节或臀部的骨关节炎疼痛：随机，双盲，安慰剂控制，十二周的研究
2. Efficacy and tolerability of sustained-release tramadol in the treatment of symptomatic osteoarthritis of the hip or knee: a multicenter, randomized, double-blind, placebo-controlled study. [J] . Malonne H, Coffiner M, Sonet B, Clinical therapeutics . 2004,第11期

机译：缓释曲马多治疗髋关节或膝关节症状的疗效和耐受性：多中心，随机，双盲，安慰剂对照研究。
3. A Phase IIIb, Multicentre, Randomised, Parallel-Group, Placebo-Controlled, Double-Blind Study to Investigate the Efficacy and Safety of OROS Hydromorphone in Subjects with Moderate-to-Severe Chronic Pain Induced by Osteoarthritis of the Hip or the Knee [J] . JozefVojta??ák, AdamJacobs, LeonieRynn, Pain Research and Treatment . 2011,第1期

机译：IIIb期，多中心，随机，平行组，安慰剂对照，双盲研究旨在研究OROS氢吗啡酮在中度至重度由髋或膝骨关节炎引起的中度至重度慢性疼痛患者中的疗效和安全性
4. A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL TRIAL TO INVESTIGATE THE EFFICACY OF TIAMULIN IN THE CONTROL OF PORCINE PROLIFERATIVE ENTEROPATHY (PPE) AND PORCINE COLONIC SPIROCHAETOSIS (PCS) UNDER FIELD CONDITIONS [C] . J. Haugegaard, K. Moller, T.K. Jensen, Congress of the International Pig Veterinary Society . 2000

机译：一种双盲随机安慰剂对照临床试验，探讨硫霉素在野生植物中猪增殖肠病（PPE）和猪结肠螺旋肌肤症（PCS）的疗效
5. The efficacy of hip strengthening exercises compared to leg strengthening exercises on knee pain, function and quality of life in patients with knee osteoarthritis. [D] . Marsh, Andrew David. 2010

机译：与腿部强化锻炼相比，髋部强化锻炼在膝关节骨关节炎患者中在膝关节疼痛，功能和生活质量方面的功效。
6. A Phase IIIb Multicentre Randomised Parallel-Group Placebo-Controlled Double-Blind Study to Investigate the Efficacy and Safety of OROS Hydromorphone in Subjects with Moderate-to-Severe Chronic Pain Induced by Osteoarthritis of the Hip or the Knee [O] . Jozef Vojtaššák, Jozef Vojtaššák, Adam Jacobs, 2011

机译：IIIb期多中心随机平行组安慰剂对照双盲研究旨在研究OROS氢吗啡酮在中度至重度由髋或膝骨关节炎引起的中度至重度慢性疼痛患者中的疗效和安全性
7. Three-month efficacy and safety of acetaminophen extended-release for osteoarthritis pain of the hip or knee: a randomized, double-blind, placebo-controlled study [O] . Altman R.D., Zinsenheim J.R., Temple A.R., 2007

机译：对乙酰氨基酚缓释对髋部或膝盖骨关节炎疼痛的三个月疗效和安全性：一项随机，双盲，安慰剂对照研究

Efficacy and safety of twice daily sustained-release paracetamol formulation for osteoarthritis pain of the knee or hip: a randomized, double-blind, placebo-controlled, twelve-week study

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