Ineffective Hematopoiesis in Cases of Myelodysplastic Syndromes the Role of CD34+ Stem and Progenitor Cells

摘要

Myelodysplastic syndromes (MDS) are a heterogenous group of disorders characterized by ineffective hematopoiesis as a result of bone marrow cell dysplasia. MDS may result due to changes in the hematopoietic stem cells (HSCs), inequilibrium between programmed cell death (apoptosis) and cell proliferation and often develops after chemo- and/or X-ray therapy. It's determined that ineffective erythropoiesis (the most common disorder of MDS) is primarily due to increased intramedullar apoptosis of differentiated erythroid cells and not as much to changes in the immature CD34+ hematopoietic progenitor cells. There are promising results showing improved erythropoiesis when HSCs or erythroid progenitors are cultured in vitro in the presence of different growth factors.