Bromelain Degrades A beta 1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients

Sancesario Giulia M.; Nuccetelli Marzia; Cerri Andrea; Zegeer Joshua; Severini Cinzia; Ciotti Maria T.; Pieri Massimo; Martorana Alessandro; Caltagirone Carlo; Nistico Robert; Bernardini Sergio

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Bromelain Degrades A beta 1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients

机译：菠萝蛋白酶降解了β1-42单体和可溶性聚集体：在阿尔茨海默病患者的脑脊液中进行体外研究

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Background: Therapeutic approaches targeting amyloid beta(42) (A beta(42)) oligomers may represent a promising neuroprotective strategy for the prevention and treatment of Alzheimer's disease (AD).

机译：背景技术：靶向淀粉样蛋白β（42）的治疗方法（β（42））低聚物可以代表预防和治疗阿尔茨海默病（AD）的有希望的神经保护策略。

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来源
《Current Alzheimer research》 |2018年第7期|共9页
作者
Sancesario Giulia M.; Nuccetelli Marzia; Cerri Andrea; Zegeer Joshua; Severini Cinzia; Ciotti Maria T.; Pieri Massimo; Martorana Alessandro; Caltagirone Carlo; Nistico Robert; Bernardini Sergio;
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作者单位

Santa Lucia Fdn IRCCS Dept Clin &

Behav Neurol Via Ardeatina 306 I-00179 Rome Italy;

Univ Roma Tor Vergata Dept Expt Med &

Surg Rome Italy;

Univ Roma Tor Vergata Dept Syst Med Rome Italy;

Univ Roma Tor Vergata Dept Expt Med &

Surg Rome Italy;

CNR Inst Cell Biol &

Neurobiol Via Fosso di Fiorano 64 I-00143 Rome Italy;

EBRI Fdn Via Fosso di Fiorano 64 I-00143 Rome Italy;

Univ Roma Tor Vergata Dept Expt Med &

Surg Rome Italy;

Univ Roma Tor Vergata Dept Syst Med Rome Italy;

Santa Lucia Fdn IRCCS Dept Clin &

Behav Neurol Via Ardeatina 306 I-00179 Rome Italy;

EBRI Fdn Via Fosso di Fiorano 64 I-00143 Rome Italy;

Univ Roma Tor Vergata Dept Expt Med &

Surg Rome Italy;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
Amyloid beta(42); aggregation; bromelain; Alzheimer's disease; AD therapy; prevention;

机译：淀粉样蛋白β（42）;聚集;菠萝蛋白酶;阿尔茨海默病;AD治疗;预防;

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专利

1. Bromelain Degrades A beta 1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients [J] . Sancesario Giulia M., Nuccetelli Marzia, Cerri Andrea, Current Alzheimer research . 2018,第7期

机译：菠萝蛋白酶降解了β1-42单体和可溶性聚集体：在阿尔茨海默病患者的脑脊液中进行体外研究
2. Amyloid beta 1-42 and tau in the cerebrospinal fluid of renal failure patients for the diagnosis of Alzheimer's disease [J] . Shea Yat Fung, Chu Leung-wing, Mok Ming-yee Maggie, Journal of nephrology. . 2014,第2期

机译：肾衰竭患者脑脊液中淀粉样蛋白1-42和tau蛋白可诊断阿尔茨海默氏病
3. Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. [J] . Mehta PD, Pirttila T, Patrick BA, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2001,第1a2期

机译：阿尔茨海默氏病患者匹配的脑脊液和血浆中淀粉样蛋白1-40和1-42的水平。
4. The "O-Acyl Isopeptide Method" for the Synthesis of Alzheimer's Disease-Related Amyloid beta Peptide (Abeta) 1-42 [C] . Youhei Sohma, Maiko Kimura, Yousuke Chiyomori American Peptide Symposium . 2006

机译：用于合成阿尔茨海默病相关淀粉样蛋白β肽（ABETA）1-42的“O-酰基异肽法”
5. Amyloid beta-peptide (1-42)-mediated oxidative stress and neurotoxicity: I. The role of methionine 35. II. Proteomic identification of specifically oxidized proteins in models of Alzheimer's disease. [D] . Boyd-Kimball, Debra Lynn. 2004

机译：淀粉样β-肽（1-42）介导的氧化应激和神经毒性：I.蛋氨酸的作用35. II。蛋白质组学鉴定阿尔茨海默病模型中特定氧化的蛋白质。
6. Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. [O] . W E Van Nostrand, S L Wagner, W R Shankle, 1992

机译：生活阿尔茨海默氏病患者的脑脊液中可溶性淀粉样β蛋白前体水平降低。
7. Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. [O] . Van Nostrand, W E, Wagner, S L, Shankle, W R, 1992

机译：生活阿尔茨海默氏病患者的脑脊液中可溶性淀粉样β蛋白前体水平降低。

Bromelain Degrades A beta 1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients

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