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Critical evaluation of assays for vitamin D status

机译:维生素D状态测定的关键评估

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摘要

PURPOSE OF REVIEW: The objective is to highlight new aspects and methodological developments in the assessment of vitamin D status in clinical settings. RECENT FINDINGS: Recent advances in the assessment of vitamin D status mostly concern two areas: the emerging clinical and analytical interest in other circulating vitamin D metabolites [i.e. 3-epimer and 24,25-(OH)2 D] that opens a new perspective for the vitamin D metabolite profiling in health and disease and methodological improvements including the development of reference measurement procedures, the certification of Standard Reference Materials, the development and application of Standardization protocols and the change of the Vitamin D External Quality Assurance Survey (DEQAS) to an accuracy-based proficiency testing scheme. SUMMARY: Despite the improvement in the analytical imprecision between methods and laboratories over the last years, the reported prevalence of vitamin D deficiency in a given population still depends on the method used. Improvements in quality control procedures, however, will improve the standardization, accuracy and comparability of methods. At present, the analytical evaluation of other circulating vitamin D metabolites (vitamin D profiling) and their clinical utility is, however, limited to liquid chromatography users.
机译:审查目的:目的是突出临床环境中对维生素D状态评估的新方面和方法论发展。最近的发现:维生素D的评估的最新进展主要是两个领域:其他循环维生素D代谢物的新出现的临床和分析兴趣[即3-eBimer和24,25-(OH)2 D],为健康和疾病的维生素D代谢物分析开辟了一种新的视角,以及方法改进,包括发展参考测量程序,标准参考资料认证,开发和发展标准化协议的应用及维生素D外部质量保证调查(DEQAS)的改变为基于精确的能力测试方案。摘要:尽管过去几年方法和实验室之间的分析不精确改善,但报道的维生素D缺乏在给定人群中的患病率仍然取决于所用方法。然而,质量控制程序的改进将提高方法的标准化,准确性和可比性。目前,其他循环维生素D代谢物(维生素D分析)的分析评价及其临床效用仅限于液相色谱使用者。

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