Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

摘要

Objective: To assess the relationship between maternal serum uric acid and severity ofHypertensive disorders of pregnancy in a rural tertiary care centre.Materials and Methods: Present study was conducted in Obstetrics and Gynaecology department ofrural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Preeclampsia,Eclampsia) at ≥34 weeks gestation. Maternal serum uric acid levels were compared inthree groups in relation to disease severity, mode of delivery, maternal outcome.Results: Of total 110 women with a Hypertensive disorder of pregnancy; 35 (31.81%) had GestationalHypertension, 49 (44.54%) preeclampsia and 26 (23.63%) had eclampsia. Mean±SD valuesfor serum uric acid were 5.47±1.93 mg/dl in women with Gestational Hypertension; 6.72±2.15mg/dl in Pre-eclampsia and 8.71±2.97 mg/dl in the eclamptic group. Of 110 women 34(97.14%)with gestational hypertension, 27(55.10%) with pre-eclampsia and one (3.85%) with eclampsiaremained stable in post-partum period, 17 (34.69%) women with severe pre-eclampsia and 15(57.69%) with eclampsia required intensive care in postpartum period and one (2.86%) women withgestational hypertension, five (10.20%) with pre-eclmapsia and ten (38.46%) with eclampsia requiredventilator support and high dependency unit care. Of these 16 women with the severe disease,ten succumbed to death. Also, in women with serum uric acid,>6mg/dl, most common modeof delivery was a lower segment cesarean section (50.90%).Conclusion: Significant correlation was observed between maternal serum uric acid, disease severityand maternal outcome.