Preclinical Assessment of Steroidal Nanostructured Lipid Carriers Based Gels for Atopic Dermatitis: Optimization and Product Development

摘要

Background: Betamethasone Valerate (BV) is a potent topical corticosteroid. Preparation of nanostructured lipid earners (NLC) involves process parameters optimization and formulations were developed. It is available in several conventional formulations like creams and ointments which have well-known problems of frequent dosing and consequently additional side effects. The aim is to ascertain the probability of NLC as an exclusive earner for betamethasone valerate topical application with _ regard to release modulation and improved therapeutic effect.