Encapsulatton of Solid Dispersion in Solid Lipid Particles for Dissolution Enhancement of Poorly Water-soluble Drug

Khanh Thi My Tran; Toi Van Vo; Lee Beom-Jin; Duan Wei; Phuong Ha-Lien Tran; Thao Truong-Dinh Tran

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Encapsulatton of Solid Dispersion in Solid Lipid Particles for Dissolution Enhancement of Poorly Water-soluble Drug

机译：固体分散体的固体分散体，用于溶解差水溶性药物的溶解增强

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Background: The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug.

机译：背景：该研究的目的是将固体分散脂质颗粒（Sds1）包封，以形成固体分散体（SD）以形成固体脂质颗粒（SLS）的核心，从而实现了较差的溶解中的有效增强水溶性药物。

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来源
《Current drug delivery》 |2018年第4期|共9页
作者
Khanh Thi My Tran; Toi Van Vo; Lee Beom-Jin; Duan Wei; Phuong Ha-Lien Tran; Thao Truong-Dinh Tran;
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作者单位

Vietnam Natl Univ Int Univ Biomed Engn Dept Pharmaceut Engn Lab Ho Chi Minh City Vietnam;

Vietnam Natl Univ Int Univ Biomed Engn Dept Pharmaceut Engn Lab Ho Chi Minh City Vietnam;

Ajou Univ Coll Pharm Bioavailabil Control Lab Suwon 443749 South Korea;

Deakin Univ Sch Med Waurn Ponds Vic Australia;

Deakin Univ Sch Med Waurn Ponds Vic Australia;

Vietnam Natl Univ Int Univ Biomed Engn Dept Pharmaceut Engn Lab Ho Chi Minh City Vietnam;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Crystallinity; dissolution enhancement; micro/nanoscale; solid dispersion; solid dispersion lipid particles; solid lipid particles;

机译：结晶度;溶出性增强;微/纳米级;固体分散体;固体分散脂质颗粒;固体脂质颗粒;

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专利

1. Encapsulatton of Solid Dispersion in Solid Lipid Particles for Dissolution Enhancement of Poorly Water-soluble Drug [J] . Khanh Thi My Tran, Toi Van Vo, Lee Beom-Jin, Current drug delivery . 2018,第4期

机译：固体分散体的固体分散体，用于溶解差水溶性药物的溶解增强
2. Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: Generation of solvent-free drug-polymer solid dispersions [J] . Yang C., Xu X., Wang J., Chemical and Pharmaceutical Bulletin . 2012,第7期

机译：使用共研磨方法增强水溶性差的药物的溶解行为：生成无溶剂的药物-聚合物固体分散体
3. Use of the Co-grinding Method to Enhance the Dissolution Behavior of a Poorly Water-Soluble Drug: Generation of Solvent-Free Drug–Polymer Solid Dispersions [J] . Chemical and Pharmaceutical Bulletin . 2012,第7期

机译：使用共研磨方法增强水溶性差的药物的溶解行为：无溶剂药物-聚合物固体分散体的产生
4. Solid Dispersion versus Particle Size Reduction to Improve the Dissolution Rateof a Poorly Water-Soluble Drug Substance from Fast-Disintegrating Tablets [C] . Emilie Allard, Jean-Manuel Péan, Hervé Rolland, Annual meeting exposition of the Controlled Release Society . 2005

机译：固体分散体与减小粒径的关系，以改善速溶片剂中水溶性差的药物的溶出度
5. Enhancement of in-vitro drug dissolution of ketoconazole for its optimal in-vivo absorption using Nanoparticles and Solid Dispersion forms of the drug. [D] . Syed, Mohammed Irfan. 2013

机译：使用药物的纳米颗粒和固体分散体形式，可提高酮康唑的体外药物溶解度，以实现最佳的体内吸收。
6. Studies on Dissolution Enhancement of Prednisolone a Poorly Water-Soluble Drug by Solid Dispersion Technique [O] . Parvin Zakeri-Milani, Somayeh Hallaj Nezhadi, Mohammad Barzegar-Jalali, 2011

机译：固体分散技术提高水溶性差的药物泼尼松龙的溶出度研究
7. Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [O] . Parvin Zakeri-Milani, Somayeh Hallaj Nezhadi, Mohammad Barzegar-Jalali, 2011

机译：固体分散技术研究水溶性差的泼尼松龙的溶出度增强作用

Encapsulatton of Solid Dispersion in Solid Lipid Particles for Dissolution Enhancement of Poorly Water-soluble Drug

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