PLGA Nanoparticles and Polysorbate-80-coated PLGA Nanoparficles Increase the in vitro Antioxidant Activity of Melatonin

Martins Leiziani Gnatkowski; Khalil Najeh Maissar; Mainardes Rubiana Mara

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PLGA Nanoparticles and Polysorbate-80-coated PLGA Nanoparficles Increase the in vitro Antioxidant Activity of Melatonin

机译：PLGA纳米粒子和多晶硅酸盐-80涂覆的PLGA纳米尾粉粉尾粉状蛋白增加了褪黑素的体外抗氧化活性

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Background: Melatonin is an endogen substance with several physiological functions, acting as an important antioxidant. Our objective was to prepare nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 (PLGA-PS80) or uncoated (PLGA) nanoparticles containing melatonin (MLT) and evaluate their in vitro cytotoxicity over erythrocytes and in vitro antioxidant activity.

机译：背景：褪黑激素是一种具有若干生理功能的内源性物质，作为重要的抗氧化剂。我们的目的是制备由涂覆有聚山梨醇酯80（PLGA-PS80）或未涂覆的（PLGA）纳米颗粒的聚（乳酸二乙醇酸）（PLGA）组成的纳米颗粒，含有褪黑素（MLT），并通过红细胞和在红细胞上进行体外细胞毒性。体外抗氧化活性。

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来源
《Current drug delivery》 |2018年第4期|共10页
作者
Martins Leiziani Gnatkowski; Khalil Najeh Maissar; Mainardes Rubiana Mara;
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作者单位

Univ Estadual Centrooeste UNICENTRO Dept Pharm Rua Simeao Camargo Varela de Sa03 BR-85040080;

Univ Estadual Centrooeste UNICENTRO Dept Pharm Rua Simeao Camargo Varela de Sa03 BR-85040080;

Univ Estadual Centrooeste UNICENTRO Dept Pharm Rua Simeao Camargo Varela de Sa03 BR-85040080;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Antioxidant; cytotoxicity; hemolysis; melatonin; nanoparticles; PLGA;

机译：抗氧化剂;细胞毒性;溶血;褪黑素;纳米颗粒;PLGA;

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1. PLGA Nanoparticles and Polysorbate-80-coated PLGA Nanoparficles Increase the in vitro Antioxidant Activity of Melatonin [J] . Martins Leiziani Gnatkowski, Khalil Najeh Maissar, Mainardes Rubiana Mara Current drug delivery . 2018,第4期

机译：PLGA纳米粒子和多晶硅酸盐-80涂覆的PLGA纳米尾粉粉尾粉状蛋白增加了褪黑素的体外抗氧化活性
2. Investigation of in vitro antioxidant activity of quercetin loaded PLGA nanoparticles [J] . Uzunoglu D., Acar T., Mansuroglu B., The FEBS journal . 2016,第Suppla1期

机译：槲皮素负载的PLGA纳米粒子的体外抗氧化活性研究
3. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (vol 79, pg 330, 2010) [J] . Anand Preetha, Nair Hareesh B., Sung Bokyung, Biochemical Pharmacology . 2016,第Null期

机译：姜黄素负载的PLGA纳米颗粒制剂的设计具有增强的细胞吸收能力，更高的体外生物活性和更高的体内生物利用度（第79卷，第330页，2010年）
4. Time Release and Thermal Stability of Aloe vera (Aloe barbadensis) Gel Loaded PLGA Nanoparticles and Its Antioxidant Activity [C] . Annual International Meeting of the American Society of Agricultural and Biological Engineers . 2017

机译：芦荟（芦荟（Aloe Barbadensis）凝胶负载PLGA纳米粒子及其抗氧化活性的时间释放和热稳定性
5. Formulation and delivery of drugs for macular edema and retinoblastoma; synthesis and in vitro characterization of doxorubicin loaded surface modified nanoparticles using PLGA-PEG-FOL polymer. [D] . Boddu, Sai Hanuman Sagar. 2010

机译：黄斑水肿和视网膜母细胞瘤药物的配制和投放； PLGA-PEG-FOL聚合物合成负载阿霉素的表面改性纳米粒子的合成和体外表征。
6. Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake and Increased Bioactivity in vitro and Superior Bioavailability in vivo [O] . Preeta Anand, Harish B. Nair, Bokyung Sung, -1

机译：姜黄素加载PLGA纳米粒子配方的设计具有增强的细胞摄取以及体内体外生物活性的增强和卓越的生物利用度
7. RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo [O] . Preetha Anand, Hareesh B. Nair, Bokyung Sung, 2010

机译：缩回：姜黄素加载的PLGA纳米颗粒的设计，具有增强的细胞摄取，并在体外增加生物活性和优异的生物利用度

PLGA Nanoparticles and Polysorbate-80-coated PLGA Nanoparficles Increase the in vitro Antioxidant Activity of Melatonin

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