Liposomal Formulation of a Melphalan Lipophilic Prodrug: Studies of Acute Toxicity, Tolerability, and Antitumor Efficacy

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Liposomal Formulation of a Melphalan Lipophilic Prodrug: Studies of Acute Toxicity, Tolerability, and Antitumor Efficacy

机译：Melphalan亲脂性能的脂质体制性：急性毒性，耐受性和抗肿瘤功效的研究

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Background: Recently we developed a scalable scheme of synthesis of melphalan ester conjugate with 1,2-dioleoyl-sn-glycerol (MlphDG) and a protocol for the fabrication of its lyophilized liposomal formulation.

机译：背景：最近，我们开发了一种可扩展的Melphalan酯缀合物与1,2-Dioleyl-Sn-甘油（MLPHDG）合成的可扩展方案，以及制备其冻干脂质体制剂的方案。

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《Current drug delivery》 |2020年第4期|共12页
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正文语种 eng
中图分类药学;
关键词
Melphalan; lipophilic prodrug; lyophilized nano-sized liposomes; natural phospholipids; acute toxicity in rats; hemopoiesis; mouse breast cancer; antitumor efficacy;

机译：Melphalan;亲脂前药;冻干纳米大小的脂质体;天然磷脂;大鼠急性毒性;血液血液;小鼠乳腺癌;抗肿瘤功效;

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1. Liposomal Formulation of a Melphalan Lipophilic Prodrug: Studies of Acute Toxicity, Tolerability, and Antitumor Efficacy [J] . Current drug delivery . 2020,第4期

机译：Melphalan亲脂性能的脂质体制性：急性毒性，耐受性和抗肿瘤功效的研究
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Liposomal Formulation of a Melphalan Lipophilic Prodrug: Studies of Acute Toxicity, Tolerability, and Antitumor Efficacy

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