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Vascular endothelial growth factor: An important molecular target of curcumin

机译:血管内皮生长因子:姜黄素的重要分子靶标

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The discovery of Vascular Endothelial Growth Factor (VEGF), the key modulator of angiogenesis, has triggered intensive research on anti-angiogenic therapeutic modalities. Although several clinical studies have validated anti-VEGF therapeutics, with few of them approved by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy is still in its infancy. Phytochemicals are compounds that have several metabolic and health benefits. Curcumin, the yellow pigment derived from turmeric (Curcuma longa L.) rhizomes, has a wide range of pharmaceutical properties. It has also been shown to inhibit VEGF by several studies. In this review, we elaborate the effect of curcumin on VEGF and angiogenesis and its therapeutic application.
机译:血管内皮生长因子(VEGF)的发现,血管生成的关键调节剂引发了对抗血管生成治疗方式的密集研究。 虽然几项临床研究已经验证了抗VEGF治疗剂,但其中很少有美国食品和药物管理局(FDA),抗血管生成治疗仍处于其初期。 植物化学品是具有若干代谢和健康益处的化合物。 姜黄素,来自姜黄(Curcuma Longa L.)根茎的黄色颜料,具有广泛的药物性质。 它也被抑制了几项研究抑制了VEGF。 在本综述中,我们详细阐述了姜黄素对VEGF和血管生成的影响及其治疗应用。

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