Maternal weight gain in twin-twin transfusion syndrome.

摘要

OBJECTIVE: To examine the association between maternal weight gain and twin-twin transfusion syndrome (TTTS). DESIGN: Retrospective observational study in two tertiary care centers. POPULATION: All 124 women with monochorionic diamniotic twin pregnancies who gave birth at >/= 16 gestational weeks between 2002 and 2010. METHODS: Analysis of chronological relation between maternal weight gain per week (weekly gain) and the diagnosis of TTTS. MAIN OUTCOME MEASURE: Sonographic diagnosis of TTTS. RESULTS: A weekly weight gain >/= 1.4 kg occurred in 45 women, preceded the diagnosis of TTTS in 22 (78.6%) of the 28 women with TTTS, and was associated with TTTS [women with one weekly weight gain >/= 1.4 kg vs. women with no weekly weight gains >/=1.4 kg who were diagnosed as having TTTS: 48.9% (22/45) vs. 7.6% (6/79); RR, 6.44; 95%CI, 2.82-14.69]. At given gestational weeks between 16 and 27, the mean (+/- SD) prospective risk of the development of TTTS within three weeks was 52.0 +/- 33.8% among women who showed a weekly weight gain >/= 1.4 kg for the first time, whereas the risk of the development of TTTS within one week was 1.6 +/- 1.7% among women who never showed a weekly weight gain >/= 1.4 kg. CONCLUSIONS: Excessive maternal weight gain >/= 1.4 kg/week is likely to occur during the development of TTTS.