An exploratory evaluation of Take Control: A novel computer-deliver* behavioral platform for placebo-controlled pharmacotherapy trials fc alcohol use disorder

摘要

Effective evaluation of medications for the treatment of alcohol use disorder (AUD) hinges on a strong placebo-controlled design. Studies that provide only a placebo without standard care, however, place subjects at an unacceptable level of risk of morbidity and mortality [1-3] from an otherwise preventable disease with a range of effective treatment options [4], Industry guidelines encourage the use of an active control, which provides an established treatment when testing medications for a serious illness, when satisfactory treatments are available [5].