Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury

Arulkumaran Nishkantha; Pollen Sean; Greco Elisabetta; Courtneidge Holly; Hall Andrew M.; Duchen Michael R.; Tam Frederick W. K.; Unwin Robert J.; Singer Mervyn

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Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury

机译：尽管在实验性化脓性急性肾损伤中保存了肾脏氧输送，但肾小管线粒体功能障碍发生了肾小管线粒体功能障碍

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Objective: To explain the paradigm of significant renal functional impairment despite preserved hemodynamics and histology in sepsis-induced acute kidney injury.

机译：目的：尽管脓毒症诱导的急性肾损伤存在血流动力学和组织学，但是解释显着肾功能损伤的范式。

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来源
《Critical care medicine》 |2018年第4期|共8页
作者
Arulkumaran Nishkantha; Pollen Sean; Greco Elisabetta; Courtneidge Holly; Hall Andrew M.; Duchen Michael R.; Tam Frederick W. K.; Unwin Robert J.; Singer Mervyn;
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作者单位

UCL Bloomsbury Inst Intens Care Med Div Med London England;

UCL Bloomsbury Inst Intens Care Med Div Med London England;

UCL Bloomsbury Inst Intens Care Med Div Med London England;

UCL Div Med UCL Ctr Nephrol Royal Free Campus &

Hosp London England;

Univ Zurich Inst Anat Winterthurerstr Zurich Switzerland;

UCL Dept Cell &

Dev Biol London England;

Imperial Coll London Kidney &

Transplant Inst Hammersmith Hosp Imperial Coll London England;

UCL Div Med UCL Ctr Nephrol Royal Free Campus &

Hosp London England;

UCL Bloomsbury Inst Intens Care Med Div Med London England;

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原文格式 PDF
正文语种 eng
中图分类护理学;
关键词
acute kidney injury; animal model; bioenergetics; sepsis;

机译：急性肾脏损伤;动物模型;生物植物;败血症;

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专利

1. Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury [J] . Arulkumaran Nishkantha, Pollen Sean, Greco Elisabetta, Critical care medicine . 2018,第4期

机译：尽管在实验性化脓性急性肾损伤中保存了肾脏氧输送，但肾小管线粒体功能障碍发生了肾小管线粒体功能障碍
2. Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis- Induced Acute Kidney Injury [J] . Gao Youguang, Zeng Zhenhua, Li Tao, Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2015,第5期

机译：多肽抑制脓毒症诱发的急性肾损伤大鼠模型肾小管上皮细胞线粒体功能障碍
3. Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times [J] . Sung-Man Oh, Gunhyuk Park, Seung Hoon Lee, BMC Complementary and Alternative Medicine . 2017,第1期

机译：通过通过分布铂与不同剂量和暴露时间处理的肾近端管状细胞的生物标志物HMGB1，NGAL和KIM-1治疗单次草药治疗后的肾病和肾急性肾损伤的回收率
4. SELECTIVE RENAL INTRA-ARTERIAL (IA) AND NON-SELECTIVE INTRAVENOUS (IV) DELIVERY OF AUTOLOGOUS MESENCHYMAL-DERIVED STEM CELLS (MSC) IN CANINE AND FELINE PATIENTS WITHACUTE AND CHRONIC KIDNEY DISEASE [C] . Allyson Berent Conference of the American College of Veterinary Internal Medicine . 2013

机译：在犬和哺乳动物患者中，在犬和哺乳动物患者中，选择性肾内动脉（IA）和非选择性静脉内（IV）递送自体间充质衍生的干细胞（MSC）
5. Evaluation of Renal Injury and Maternal Health in Rodents with a History of HELLP Syndrome with and without Acute Kidney Injury [D] . Szczepanski, Jamie L. 2020

机译：啮齿动物肾伤和孕产妇健康评估，患有急性肾损伤的Hellp综合征史
6. Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury [O] . Nishkantha Arulkumaran, Sean Pollen, Elisabetta Greco, -1

机译：尽管在实验性脓毒性急性肾损伤中保存了肾脏氧气但仍发生了肾小管细胞线粒体功能障碍。
7. Renal tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury [O] . Tam, FWK, Arulkumaran, N, Pollen, S, 2018

机译：尽管在实验性脓毒性急性肾损伤中保留了肾氧输送，但仍发生肾小管细胞线粒体功能障碍

Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury

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