The Effect of a Cationic Gemini Surfactant, Ethonium, on the Physicochemical Properties of Quercetin in Solutions and on the Surface of Highly Dispersed Silica

摘要

The formation of supramolecular complexes with ethonium, a cationic gemini surfactant having a broad-spectrum antimicrobial activity, is shown to significantly alter the physicochemical properties (spectral, protolytic, and adsorption properties and solubility) of a natural f lavonol, quercetin. The constant of binding between quercetin and ethonium is calculated. Apparent dissociation constants pK (a1) (a) of quercetin in solutions of this cationic surfactant are for the first time determined within a broad concentration range. A shift in the pH dependence of quercetin adsorption by 0.5 units to the alkaline region upon the transition from a premicellar ethonium solution to a micellar one correlates with an increase in pK (a1) (a) under these conditions. The value of quercetin adsorption from aqueous ethonium solutions depends on the concentration of the cationic surfactant, pH of a solution, and the pK (a1) (a) value of the f lavonol bound into the supramolecular complex.