Endometriosis-induced changes in regulatory T cells - Insights towards developing permanent contraception

摘要

Background Endometriosis is a gynecological disorder that is associated with alterations in the immune system that contributes to its pathology as well as its associated infertility. Main Findings This brief report summarizes our findings related to the changes in T regulatory cells (Tregs) that may affect the uterine environment and impact the fertility of women and nonhuman primates with endometriosis. Principal Conclusion: Targeted therapies that could reduce Tregs within the reproductive tract may have a potential as long-lasting or permanent contraception. ? 2015 Elsevier Inc.