Synthesis and characterization of thermoresponsive hydrogels cross-linked with acryloyloxyethylaminopolysuccinimide

摘要

Biodegradable cross-linkers acryloyloxyethyl-aminopolysuccinimide (AEA-PSI) were obtained by microwave irradiation using maleic anhydride as materials.With AEA-PSI cross-linker,cross-linked poiy(iV-isopropylacrylamide-co-acrylic acid) [P(NIPAAm-co-AAc)] hydrogels were prepared,and their phase transition behavior,lower critical solution temperature (LCST),water content,thermodynamics stability,and enzymatic degradation properties were investigated.By alternating the NIPAAm/AAc molar ratio,hydrogels were synthesized to have LCST in the vicinity of 37 °C.The LCST of AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was significantly influenced by monomer ratio of the NIPAAm/AAc but not by the cross-linking density within the polymer network.The water content of AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was more than 90% even at 37 °C,which was controlled by the monomer molar ratio of NIPAAm/AAc,swelling media,and the cross-linking density.The thermodynamics stability was also characterized by thermogravimetry.In enzymatic degradation studies,breakdown of the AEA-PSI-cross-linked P(NIPAAm-co-AAc) hydrogels was "dependent on the cross-linking density.