The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis

Fantin B.; Poujade J.; Gregoire N.; Chau F.; Roujansky A.; Kieffer N.; Berleur M.; Couet W.; Nordmann P.

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The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis

机译：大肠杆菌表达MCR-1的接种效应与腹膜炎小鼠模型中的菌根活性

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Objectives: Colistin often remains the last resort antibiotic active against carbapenemase-producing Enterobacteriaceae. However, while in vitro inoculum effect has been reported, therapeutic relevance of this phenomenon remains questioned.

机译：目的：Colistin通常仍然是对碳基胺酶产生的肠杆菌菌的最后一个度假抗生素。然而，虽然据报道，虽然在体外接种效应，但这种现象的治疗相关性仍有质疑。

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《Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases》 |2019年第12期|共4页
作者
Fantin B.; Poujade J.; Gregoire N.; Chau F.; Roujansky A.; Kieffer N.; Berleur M.; Couet W.; Nordmann P.;
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作者单位

INSERM UMR 1137 IAME F-75018 Paris France;

INSERM UMR 1137 IAME F-75018 Paris France;

Univ Poitiers INSERM UMR1070 Sch Med &

Pharm Poitiers France;

INSERM UMR 1137 IAME F-75018 Paris France;

INSERM UMR 1137 IAME F-75018 Paris France;

Univ Fribourg Emerging Antibiot Resistance Unit Med &

Mol Microbiol INSERM Dept Med European;

INSERM UMR 1137 IAME F-75018 Paris France;

Univ Poitiers INSERM UMR1070 Sch Med &

Pharm Poitiers France;

INSERM UMR 1137 IAME F-75018 Paris France;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Antibiotic resistance; Colistin; Escherichia coli; MCR-1; Peritonitis; Pharmacodynamics;

机译：抗生素抗性;胚胎;大肠杆菌;MCR-1;腹膜炎;药效学;

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1. The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis [J] . Fantin B., Poujade J., Gregoire N., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2019,第12期

机译：大肠杆菌表达MCR-1的接种效应与腹膜炎小鼠模型中的菌根活性
2. Increased activity of colistin in combination with amikacin against Escherichia coli co-producing NDM-5 and MCR-1 [J] . Zhou Yu-Feng, Tao Meng-Ting, Feng Youjun, The Journal of Antimicrobial Chemotherapy . 2017,第6期

机译：Colistin的活性增加与Amikacin相对于大肠杆菌Coli共同产生NDM-5和MCR-1的活性
3. Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model [J] . Yu Yang, Walsh Timothy R., Yang Run-Shi, The Journal of Antimicrobial Chemotherapy . 2019,第1期

机译：与菌氨酸的新型合作伙伴，以增加其体内治疗效果，并防止在小鼠感染模型中产生NDM-and MCR共同的大肠杆菌耐药素抗性
4. Efficacy of tiamulin/colistin against Enterotoxigenic Escherichia coli (ETEC) and Salmonellaisolated from pigs with diarrhoea. [C] . Nuvee Prapasarakul, Watcharachai Narongsak, Waree Niyomthom, Congress ofthe International Pig Veterinary Society . 2008

机译：硫脲/菌氨酸对肠杆菌肠肠道大肠杆菌（ETEC）和泻乳糖的疗效。
5. The interaction between egg yolk and Escherichia coli in disease pathogenesis during egg yolk peritonitis. [D] . Edwards, Ingrid Cornax. 2009

机译：蛋黄腹膜炎期间疾病发病机理中，蛋黄与大肠杆菌之间的相互作用。
6. Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring tet(X) and mcr-1 [O] . Yu-Feng Zhou, Ping Liu, Shu-He Dai, 2021

机译：脱癸酸酯或菌氨酸的活性与Zidovudine相结合反对大肠杆菌窝藏Tet（X）和MCR-1
7. Expression of CTX-M-15 limits the efficacy of ceftolozane/tazobactam against Escherichia coli in a high-inoculum murine peritonitis model [O] . J. Canovas, G. Petitjean, F. Chau, 2020

机译：CTX-M-15的表达限制了头甲噻唑胺对大肠耳腹膜炎模型中大肠杆菌对大肠杆菌的疗效

The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis

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