Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail

Crespillo-Andujar C.; Chamorro-Tojeiro S.; Norman F.; Monge-Maillo B.; Lopez-Velez R.; Perez-Molina J. A.

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Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail

机译：Nifurtimox的毒性作为苯并唑氏患者苯并氮杂唑型疾病患者的二线治疗：当可用选项失败时

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Objective: To describe the tolerability and rate of nifurtimox discontinuation when administered as a second-line treatment to patients with previous treatment interruptions due to adverse reactions with benznidazole.

机译：目的：描述当苯并咪唑不良反应引起的患者作为先前治疗中断的患者的第二线治疗时，描述了Nifurtimox停止的耐受性和速率。

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来源
《Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases》 |2018年第12期|共4页
作者
Crespillo-Andujar C.; Chamorro-Tojeiro S.; Norman F.; Monge-Maillo B.; Lopez-Velez R.; Perez-Molina J. A.;
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作者单位

Univ Hosp La Paz Carlos III IdiPAZ Dept Internal Med Natl Referral Unit Trop &

Travel Med;

Univ Hosp Ramon y Cajal IRYCIS Dept Infect Dis Natl Referral Ctr Trop Dis Madrid Spain;

Univ Hosp Ramon y Cajal IRYCIS Dept Infect Dis Natl Referral Ctr Trop Dis Madrid Spain;

Univ Hosp Ramon y Cajal IRYCIS Dept Infect Dis Natl Referral Ctr Trop Dis Madrid Spain;

Univ Hosp Ramon y Cajal IRYCIS Dept Infect Dis Natl Referral Ctr Trop Dis Madrid Spain;

Univ Hosp Ramon y Cajal IRYCIS Dept Infect Dis Natl Referral Ctr Trop Dis Madrid Spain;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
Adverse drug reaction; Benznidazole; Chagas disease; Drug toxicity; Nifurtimox;

机译：不良药物反应;苯并咪唑;Chagas疾病;药物毒性;尼法温;

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1. Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail [J] . Crespillo-Andujar C., Chamorro-Tojeiro S., Norman F., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2018,第12期

机译：Nifurtimox的毒性作为苯并唑氏患者苯并氮杂唑型疾病患者的二线治疗：当可用选项失败时
2. Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment [J] . Pérez-MolinaJ.A., Sojo-DoradoJ., NormanF., Acta tropica: Journal of Biomedical Sciences . 2013,第2期

机译：Nifurtimox治疗查加斯病不会在患有苯尼达唑治疗期间曾出现此类不良反应的患者中引起超敏反应
3. Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: a prospective cohort study in two Spanish referral centres [J] . Crespillo-Andujar C., Lopez-Velez R., Trigo E., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2020,第3期

机译：两种治疗方案毒性与苯并唑氏症慢性钩蟹疾病的比较：两种西班牙推荐中心的前瞻性队列研究
4. SEARCHING FOR A NEW CHEMOTHERAPEUTIC STRATEGY AGAINST CHAGAS' DISEASE: DESIGN AND CHARACTERIZATION OF A BENZNIDAZOLE/MISONIDAZOLE LIPOSOMAL CARRIER [C] . M.J. Morilla, L.S. Bakas, E.L. Romero International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：寻找一种针对查加斯病的新化学治疗策略：苯并咪唑/咪唑并咪唑脂质体载体的设计和表征
5. The Comparison of Prescriptions Dispensed For Methadone Maintenance Patients to Non-Methadone Maintenance Patients for the Treatment of Chronic Diseases using PharmaNet Data [D] . Maruyama, Anna. 2012

机译：使用PharmaNet数据比较美沙酮维持治疗患者和非美沙酮维持治疗患者治疗慢性疾病的处方比较
6. Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas’ disease [O] . Yves Jackson, Baptiste Wyssa, François Chappuis -1

机译：成人慢性查加斯病患者对尼呋替莫和苯硝唑的耐受性
7. Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas’ disease [O] . Yves Jackson, Baptiste Wyssa, François Chappuis 2019

机译：对成年患者慢性黏膜疾病患者的Nifurtimox和Benznidazole的耐受性

Toxicity of nifurtimox as second-line treatment after benznidazole intolerance in patients with chronic Chagas disease: when available options fail

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