Rapid diagnostic tests for determining dengue serostatus: a systematic review and key informant interviews

摘要

Objectives: Vaccination for dengue with the live attenuated tetravalent CYD-TDV vaccine (Dengvaxia (R)) is only recommended in individuals who have had prior dengue virus (DENV) infection. Rapid diagnostic tests (RDT) for past DENV infection would offer a convenient method for pre-vaccination screening at point-of-care. A systematic review was conducted to evaluate the performance of current dengue RDTs for determining dengue serostatus, using IgG antibodies against DENV as a marker of past infection.