Experimental study on Wistar rats: the Allium eriophyllum Boiss aqueous extract ointment effectively treat induced cutaneous wound

摘要

Cutaneous wound healing by medicinal plants which have fewer side effects than chemical drugs have been on the increase. In our study, we evaluated cutaneous wound healing potential of Allium eriophyllum Boiss aqueous extract ointment in rats. In in vivo design, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups: untreated control, treatment with Eucerin ointment, treatment with 3% tetracycline ointment, treatment with 3% A. eriophyllum aqueous extract ointment. The groups were treated for 30 days. For biochemical and histopathological analysis of the cutaneous wound healing trend, a 3 x 3 cm section was prepared from all dermal thicknesses on days 10,20, and 30. The data were analyzed by SPSS 21 software. The use of A. eriophyllum aqueous extract ointment in the treatment groups led to remarkable reduce (p < 0.05) in the levels of wound area, total cells, neutrophil, lymphocyte, and macrophage, and remarkable increase (p < 0.05) in the levels of wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and the rate of fibrocyte to fibroblast as compared to the control and basal ointment groups. According to the findings, A. eriophyllum aqueous extract ointment can cure the cutaneous wound.