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Feasibility of Collecting Saliva for Biological Verification of Tobacco Use Status in Dental Practices and Patients' Homes: Results from the National Dental PBRN

机译:用于收集唾液的生物验证烟草使用情况和患者家庭的生物核查的可行性:国家牙科PBRN的结果

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Objective: To evaluate the feasibility of collecting and analyzing saliva samples from dental practices and patients' homes for biochemical verification of tobacco use status. Basic research design: Sub-study within single-arm, multi-center, longitudinal clinical study. Clinical setting: Dental practices in the South Central region of the United States National Dental Practice-Based Research Network and patients' homes. Participants: Fifty-five patients recruited from 30 dental practices. Interventions: Participants in the sub-study were instructed on saliva collection for cotinine analysis in dental practices where they enrolled in the primary study. Saliva was collected at the practices and then from patients' homes. Main outcome measures: Feasibility for dental practice collection was define as 80% of enrolled participants having analyzable samples. For patients' home collection, feasibility was defined as 70%. Results: Forty-seven samples (i.e., 86% of those enrolled) collected in dental practices were analyzable. Twenty-one samples (i.e. 38% of those enrolled) collected in patients' homes were analyzable. Conclusions: Collecting saliva samples for cotinine analysis from dental practices, but not from patients' homes, was feasible. Dental practices may provide an advantageous setting for biochemically verifying tobacco use status as part of clinical trials for tobacco cessation.
机译:目的:评价从牙科实践和患者家庭收集和分析唾液样本的可行性,以进行烟草使用状态的生化验证。基础研究设计:单臂,多中心,纵临临床研究中的亚研究。临床环境:美国国家牙科实践的研究网络和患者家园中部地区的牙科实践。参与者:五十五名患者从30名牙科实践中招募。干预措施:对唾液征收的参与者进行唾液收集,以便在初步研究中征收牙科实践中的Cotinine分析。在实践中收集唾液,然后从患者的家中收集。主要观察措施:牙科练习收集的可行性定义为可分析样本的登记参与者的80%。对于患者的家庭收集,可行性定义为70%。结果:在牙科实践中收集的四十七个样本(即86%的注册)是在牙科实践中收集的。分析在患者家庭中收集的二十一项样品(即38%的注册)。结论:从牙科实践中收集唾液样本,但不是来自患者的家园,是可行的。牙科实践可以为生物化学上验证烟草使用状态提供有利的设置,作为烟草停止的临床试验的一部分。

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