Early bone growth on the surface of titanium implants in rat femur is enhanced by an amorphous diamond coating.

摘要

BACKGROUND AND PURPOSE: Amorphous diamond (AD) is a durable and compatible biomaterial for joint prostheses. Knowledge regarding bone growth on AD-coated implants and their early-stage osseointegration is poor. We investigated bone growth on AD-coated cementless intramedullary implants implanted in rats. Titanium was chosen as a reference due to its well-known performance. MATERIALS AND METHODS: We placed AD-coated and non-coated titanium implants (R(a) approximately 0.2 mum) into the femoral bone marrow of 25 rats. The animals were divided in 2 groups according to implant coating and they were killed after 4 or 12 weeks. The osseointegration of the implants was examined from hard tissue specimens by measuring the new bone formation on their surface. RESULTS: 4 weeks after the operation, the thickness of new bone in the AD-coated group was greater than that in the non-coated group (15.3 (SD 7.1) mum vs. 7.6 (SD 6.0) mum). 12 weeks after the operation, the thickness of new bone was similar in the non-coated group and in the AD-coated group. INTERPRETATION: We conclude that AD coating of femoral implants can enhance bone ongrowth in rats in the acute, early stage after the operation and might be an improvement over earlier coatings.