IRM et SRM ~1H-1D in vivo a 7 T d'un modele de regeneration musculaire sur la souris

摘要

In this study, skeletal muscle degeneration-regeneration, induced by notexin (a myotoxic substance) injection is studied by Magnetic Resonance Imaging (MRI) and by histological cuts (hematoxylin/eosin and Evans blue colorations). Comparison between MR images and histological cuts results (necrosis, myoblasts replication and fusion) permits MR images interpretation. From day 0 to day 13 after notexin injection, injected zone images are very different from those realized in healthyl muscles. Preliminary localized 1D ~1H-MRS (Magnetic Resonance Spectroscopy) study is also reported.