The anionic chemistry of ynamides: A review

摘要

Ynamides have recently evolved as remarkably reactive and versatile building blocks for chemical synthesis. The development of efficient and robust methods for their preparation combined with their recent commercialization have facilitated both the design of an ever-growing number of original methods based on their unique reactivity and their use in other areas such as medicinal chemistry. One crucial aspect of the reactivity of these building blocks is based on their anionic chemistry, which has been extensively studied during the last decade and enabled not only the design and development of remarkably efficient and original reactions but also brought general answers to long-standing problems in organic chemistry and contributed to the emergence of new synthetic paradigms. In this short review, the anionic chemistry of ynamides is overviewed. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.