Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans

Kim Kyoung-Ah; Kyoung-Ah; Cha Yu-Jung; Kim; Lee Hae-Mi; Yu-JungCha; Joo Hyun-Jin; Park Ji-Young

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Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans

机译：ABCG2和ABCB1药物转运蛋白对人类心蛋白质药代动力学的影响

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Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer. Drug transporters P-glycoprotein encoded by ABCB1 and breast cancer resistance protein (BCRP) encoded by ABCG2 are involved in the transportation of bicalutamide and its treatment failure.

机译：嗜酸丁胺是一种用于治疗前列腺癌的口腔非甾体抗雄激素。由ABCG2编码的ABCB1和乳腺癌抗性蛋白（BCRP）编码的药物转运蛋白P-糖蛋白参与了与其治疗失败的配送。

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来源
《Clinica chimica acta: International journal of clinical chemistry and applied molecular biology》 |2015年第2015期|共5页
作者
Kim Kyoung-Ah; Kyoung-Ah; Cha Yu-Jung; Kim; Lee Hae-Mi; Yu-JungCha; Joo Hyun-Jin; Park Ji-Young;
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作者单位

Korea Univ Coll Med Anam Hosp Dept Clin Pharmacol &

Toxicol Seoul 136705 South Korea;

Department of Clinical Pharmacology and Toxicology Anam Hospital Korea University College of;

Korea Univ Coll Med Anam Hosp Dept Clin Pharmacol &

Toxicol Seoul 136705 South Korea;

Korea Univ Coll Med Anam Hosp Dept Clin Pharmacol &

Toxicol Seoul 136705 South Korea;

Korea Univ Coll Med Anam Hosp Dept Clin Pharmacol &

Toxicol Seoul 136705 South Korea;

Korea Univ Coll Med Anam Hosp Dept Clin Pharmacol &

Toxicol Seoul 136705 South Korea;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
Bicalutamide; Prostate cancer;

机译：嗜酸丁胺;前列腺癌;
入库时间 2022-08-20 00:01:22

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1. Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans [J] . Kim Kyoung-Ah, Kyoung-Ah, Cha Yu-Jung, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2015,第期

机译：ABCG2和ABCB1药物转运蛋白对人类心蛋白质药代动力学的影响
2. Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report [J] . Cha Yu-Jung, Ghim Jong-Lyul Journal of Korean medical science. . 2017,第9期

机译：ABCB1药物转运蛋白多态性在奥司他韦在人类体内的药代动力学中的作用：初步报告。
3. Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report [J] . Cha Yu-Jung, Ghim Jong-Lyul Journal of Korean medical science . 2017,第9期

机译：ABCB1药物转运蛋白在人类奥特拉米韦尔药代动力学中的作用：初步报告
4. Pharmaceutical Surfactants Interact Differently with the Human Efflux Transporters ABCB1 and ABCC2 [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：药物表面活性剂与人流速转运蛋白ABCB1和ABCC2相互作用
5. Nilotinib (TasignaRTM) Modulates ABCB1/PGP- and ABCG2/BCRP-mediated multidrug resistance in cancer chemotherapy. [D] . Tiwari, Amit K. 2011

机译：尼洛替尼（TasignaRTM）在癌症化疗中调节ABCB1 / PGP和ABCG2 / BCRP介导的多药耐药性。
6. ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C A) May Lead to Increased Drug Exposure [O] . Myriam El Biali, Rudolf Karch, Cécile Philippe, 2021

机译：ABCB1和ABCG2将ABCB1 / ABCG2底物的分布限制在人视网膜中ABCG2单核苷酸多态性Q141K（C.421C A）可能导致药物暴露增加
7. Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells [O] . Nikola Skoupa, Petr Dolezel, Eliska Ruzickova, 2017

机译：由姜黄素类似物EF-24诱导的凋亡既不通过氧化应激相关机制介导也没有受到人白血病细胞中主要药物转运蛋白ABCB1和ABCG2的表达的影响

Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans

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