Low KISS KISS 1 expression predicts poor prognosis for patients with colorectal cancer: A meta‐analysis

摘要

Abstract KISS 1 and KISS 1R, a novel pair of metastasis suppressors, are likely to be associated with the prognosis of colorectal cancer ( CRC ). Here, a meta‐analysis was performed to study the role of KISS 1 and KISS 1R in CRC . Heterogeneity, stability and publication bias were all estimated. Six publications describing a total of 559 CRC patients were included in the present study. Low KISS 1 expression predicted 70% higher risk of poor prognosis for general patients ( HR , 1.71; 95% CI , 1.28–2.29) and 99% higher risk for East Asian patients ( HR , 1.99; 95% CI , 1.46–2.72). Limited evidence indicated that decreased KISS 1R expression might predict poor outcome ( HR , 2.96; 95% CI , 1.51–5.82). Neither heterogeneity nor publication bias was identified. The current analyses suggest that low KISS 1 expression predicts poor overall survival among East Asian patients with CRC . Evidence on other races and KISS 1R are still insufficient, and additional studies are required to clarify the risk of CRC associated with KISS 1R by race.