Exploration of antifilarial activity of gold nanoparticle against human and bovine filarial parasites: A nanomedicinal mechanistic approach

摘要

Graphical abstractDisplay OmittedGold nanoparticles after entering into the filarial parasite damaged mitochondria, in turn, caused increase in the generation of reactive oxygen species (ROS) and induced apoptotic death.Highlights?Synthesized biopolymer inspired biogenic gold nanoparticle by green method.?Evaluated antifilarial activity of AuNPs against human parasite for the first time.?The role of oxidative stress and apoptosis towards bioactivity of AuNPs has been well documented.?In vivonon toxic effects of AuNPs in Wistar rat mode.Abstract