Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

Haffsah Iqbal; Moazzam Ali; Rabia Zeeshan; Zeeshan Mutahir; Farasat Iqbal; Muhammad Azhar Hayat Nawaz; Lubna Shahzadi; Aqif Anwar Chaudhry; Muhammad Yar; Shifang Luan; Ather Farooq Khan; Ihtesham-ur Rehman

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Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

机译：壳聚糖/羟基磷灰石（HA）/羟丙基甲基纤维素（HPMC）海绵状支架合成和评价为潜在的肺泡骨代替物

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?Fabrication of HPMC crosslinked chitosan/hydroxyapatite scaffolds.

?Favorable interconnected porous architecture and compatible mechanical strength.

?Pre-osteoblast cell viability and adhesion were supported by crosslinked scaffolds.

?HPMC cross linked scaffolds promoted differentiation of pre-osteoblast cells.

Abstract

Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA)

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图形抽象

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？制备HPMC交联壳聚糖/羟基磷灰石支架。

？有利的互联多孔架构和兼容机械st Rength。

？前骨甲细胞活力和粘附性通过交联支架支持。

？ HPMC交叉链接支架促进骨质细胞预骨细胞的分化。

抽象

肺泡骨质损失与感染有关及其增强相关是牙科植入物成功的先决条件。在目前的研究中，我们的目的是开发和评估新型冷冻干燥的乳蛋白（Cs）/羟基磷灰石（HA）

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来源
《Colloids and Surfaces, B. Biointerfaces》 |2017年第2017期|共11页
作者
Haffsah Iqbal; Moazzam Ali; Rabia Zeeshan; Zeeshan Mutahir; Farasat Iqbal; Muhammad Azhar Hayat Nawaz; Lubna Shahzadi; Aqif Anwar Chaudhry; Muhammad Yar; Shifang Luan; Ather Farooq Khan; Ihtesham-ur Rehman;
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作者单位

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Institute of Biochemistry and Biotechnology University of the Punjab;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Institute of Biochemistry and Biotechnology University of the Punjab;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences;

Interdisciplinary Research Centre in Biomedical Materials COMSATS Institute of Information Technology;

The Kroto Research Institute North Campus University of Sheffield;

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正文语种 eng
中图分类胶体化学（分散体系的物理化学）;
关键词
Chitosan scaffolds; Alveolar bone; ALP; Biodegradable polymers; Dental implants;

机译：壳聚糖脚手架;肺泡骨;alp;可生物降解的聚合物;牙科植入物;

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1. Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes [J] . Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Colloids and Surfaces, B. Biointerfaces . 2017,第期

机译：壳聚糖/羟基磷灰石（HA）/羟丙基甲基纤维素（HPMC）海绵状支架合成和评价为潜在的肺泡骨代替物
2. Investigating the effects of particle size and chemical structure on cytotoxicity and bacteriostatic potential of nano hydroxyapatite/chitosan/silica and nano hydroxyapatite/ chitosan/silver; as antibacterial bone substitutes [J] . Shima Tavakol, Mohammad Reza Nikpour, Elham Hoveizi, Journal of nanoparticle research: An interdisciplinary forum for nanoscale science and technology . 2014,第10期

机译：研究粒径和化学结构对纳米羟基磷灰石/壳聚糖/二氧化硅和纳米羟基磷灰石/壳聚糖/银的细胞毒性和抑菌潜力的影响;作为抗菌骨替代品
3. Evaluation of a novel nanocrystalline hydroxyapatite powder and a solid hydroxyapatite/Chitosan-Gelatin bioceramic for scaffold preparation used as a bone substitute material [J] . SHARMIN RAHMAN, KAZI HANIUM MARIA, MOHAMMAD SAIF ISHTIAQUE, Turkish journal of chemistry . 2020,第4期

机译：一种新型纳米晶羟基磷灰石粉和固体羟基磷灰石/壳聚糖 - 明胶生物陶瓷用作骨替代材料的支架制剂
4. Hydroxyapatite-gelatin-HPMC composite as injectable bone substitute with alendronate variation for osteoporotic bone [C] . Novita Sari, Alfian Pramudita Putra, Siswanto, International Conference on Physical Instrumentation and Advanced Materials . 2020

机译：羟基磷灰石 - 明胶-HPMC复合材料作为注射骨替代骨质疏松骨的变化
5. Design, synthesis, and initial evaluation of D-glyceraldehyde crosslinked gelatin-hydroxyapatite as a potential bone graft substitute material [D] . Florschutz, Anthony Vatroslav 2012

机译：D-甘油醛交联的明胶-羟基磷灰石作为潜在的骨移植替代材料的设计，合成和初步评估
6. FACILE SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF CELLULOSE-CHITOSAN-HYDROXYAPATITE COMPOSITE MATERIAL A POTENTIAL MATERIAL FOR BONE TISSUE ENGINEERING [O] . Tamutsiwa M. Mututuvari, April L. Harkins, Chieu D. Tran -1

机译：纤维素-壳聚糖-羟基磷灰石复合材料的骨架合成表征及抗微生物活性
7. Facile synthesis, characterization, and antimicrobial activity of cellulose-chitosan-hydroxyapatite composite material: A potential material for bone tissue engineering [O] . Tamutsiwa M. Mututuvari, April L. Harkins, Chieu D. Tran 2013

机译：纤维素 - 壳聚糖 - 羟基磷灰石复合材料的容易合成，表征和抗微生物活性：骨组织工程潜在材料
8. Histological Study on a Novel Bone Graft Substitute: Human Derived Tooth-Hydroxyapatite Compared With Coralline Hydroxyapatite. [R] . Oktar, F. N., Sayrak, H., Oezsoy, S., 2001

机译：新型骨移植替代物的组织学研究：人源性牙羟基磷灰石与珊瑚羟基磷灰石的比较。

Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes

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