PEGylated thermosensitive lipid-coated hollow gold nanoshells for effective combinational chemo-photothermal therapy of pancreatic cancer

摘要

Graphical abstractDisplay OmittedHighlights?PEGylated thermosensitive lipid-coated hollow gold nanoshells (GNS-L) were prepared.?GNS-L were co-loaded with hydrophilic gemcitabine and hydrophobic bortezomib.?NIR irradiation induced drug release for remotely controlled site-specific delivery.?GNS-L increased cellular uptake and apoptosis in pancreatic cancer cells.?Direct photothermal killing of cancer cells was observed on NIR laser irradiation.AbstractPancreatic cancer has extremely poor prognos