Temperature responsive fluorescent polymer nanoparticles (TRFNPs) for cellular imaging and controlled releasing of drug to living cells

摘要

Graphical abstractDisplay OmittedHighlights?Temperature responsive fluorescent polymer nanoparticle was synthesized.?Size variation in a temperature dependent manner was demonstrated.?Temperature-controlled releasing of drug to living cells was achieved.AbstractRecent studies have demonstrated that drug delivery by using functional nanomaterials with imaging capability could afford plenty of insightful information for the better control of the delivery process. In this work, we developed temperature responsive fluorescent nanoparticles (TRFNPs) for drug delivery and cellular imaging. The TRFNP was fabricated by one-pot co-precipitation of thermal sensitive amphiphilic block copolymers polystyrene-